IDIOPATHIC PULMONARY FIBROSIS IN THE ERA OF ANTIFIBROTIC THERAPY: SEARCHING FOR NEW OPPORTUNITIES GROUNDED IN EVIDENCE

Idiopathic pulmonary fibrosis in the era of antifibrotic therapy: Searching for new opportunities grounded in evidence

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that up to now has been associated with a poor prognosis.However, the results of the INPULSIS and ASCEND trials and the approval of nintedanib and pirfenidone have marked the beginning of a new era for IPF patients.Questions remain, however.Should these drugs be used earlie

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Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling

Lactobacillus plantarum (LP) has been shown to exhibit protective effects on intestinal barrier function in septic rats, although the regulatory mechanism has not been established.We determined whether LP imparts such protective effects in a lipopolysaccharide (LPS)-induced Caco2 cell monolayer model and whether cAMP-PKA signaling is the underlying

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Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs

Abstract Background CJ9-gD is a novel dominant-negative recombinant herpes simplex virus type 1 (HSV-1) that is completely replication-defective, cannot establish detectable latent infection in vivo, and expresses high levels of the major HSV-1 antigen glycoprotein D immediately following infection.In the present study, CJ9-gD was evaluated as a va

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Breastfeeding Knowledge and Practices among Mothers of Children under 2 Years of Age Living in a Military Barrack in Southwest Nigeria

Background: Human milk is uniquely superior as a source of nutrition for infants, and breastfeeding has many benefits.This study determined the breastfeeding knowledge and practices of women who have children aged 0-2 years living in a Naval Barracks.Methods: This descriptive cross sectional study was carried out among 220 women in a Naval Barracks

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